Tobacco has been used experimentally by cocktail-makers to create tobacco bitters by infusion in alcohol. Nicotine is highly soluble in alcohol and the lethal dose (60mg) is easily attained with a modest amount of tobacco. It is as poisonous as hydrogen cyanide. Infusion is much more effective than is smoking in extracting nicotine. You've been warned.
Reference: Darcy O'Neil is a chemist and has written about the risks of tobacco in cocktails for his blog, Art of Drink. If you are considering using tobacco, read it.
Some popular cocktails containing Tobacco (caution!)
- Ashby Swizzle — Herbal liqueur, Mezcal, Falernum, Bitters, Pineapple juice, Lime juice, Mint
- The French Connection — Tequila, Mezcal, Applejack, Herbal liqueur, Bitters