Stir with ice, strain into chilled cocktail glass. Optional orange twist over glass.
Calisaya is a cinchona (quinine) based liqueur style that generally benefits from a light touch in cocktails. It was an early pre-Prohibition amaro/bitter that disappeared around Prohibition, but has been revived in recent years. Pikesville is 110 proof, so it has some punch combined with the quinine--keep that in mind when making substitutions. The sassafras and sorghum bitters are semi-optional, broadening the flavor palette.
In this 250th year since the signing of the Declaration of Independence, this cocktail uses centennial (1876) era ingredients for a libation loosely hewing to a Boulevardier form. Pikesville Rye was originally a Maryland rye product, and the Maryland Line was the name used for Maryland's stalwart regiments in the Continental Army.